@article {73037, title = {Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble}, journal = {Journal of the American Chemical Society}, volume = {140}, number = {23}, year = {2018}, month = {Jun}, pages = {7256-7266}, isbn = {0002-7863}, doi = {10.1021/jacs.8b03490}, author = {A. R. Buller and van Roye, P. and Cahn, J. K. B. and Scheele, R. A. and Herger, M. and Arnold, F. H.} }